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antidepressant, any of a wide range of drugs used to treat psychic depression. They are given to elevate mood, counter suicidal thoughts, and increase the effectiveness of psychotherapy. Before the introduction of such drugs in the late 1950s, most patients with major depression had no recourse but hospitalization; only 45% improved after one year. In contrast, 80–90% of such patients can expect significant relief from depression with one of the medications now prescribed. Antidepressants act on the flow of the neurotransmitters epinephrine, serotonin, and norepinephrine across neural synapses.
Common antidepressants include monamine oxidase inhibitors (MAOIs) such as isocarboxazid (Marplan), tricyclics such as imipramine (Tofranil) and amitriptyline (Elavil), and the newer serotonin increasers as fluoxetine (Prozac) and sertraline HCL (Zoloft). The choice of antidepressant often has more to do with its side effects (variously sedation, constipation, hypotension, tachycardia) than efficacy, as they are generally regarded to be equally effective. The newer drugs, especially fluoxetine, are tolerated better and are currently by far the most widely prescribed.
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