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clone, group of organisms, all of which are descended from a single individual through asexual reproduction, as in a pure cell culture of bacteria. Except for changes in the hereditary material that come about by mutation, all members of a clone are genetically identical. Laboratory experiments in in vitro fertilization of human eggs led in 1993 to the "cloning" of human embryos by dividing such fertilized eggs at a very early stage of development, but this technique actually produces a twin rather than a clone. In a true mammalian clone the nucleus from a body cell of an animal is inserted into an egg, which then develops into an individual that is genetically identical to the original animal.
Later experiments in cloning resulted in the development of a sheep from a cell of an adult ewe (in Scotland, in 1996), and since then rodents, cattle, swine, and other animals have also been cloned from adult animals. Despite these trumpeted successes, producing cloned mammals is enormously difficult, with most attempts ending in failure; cloning succeeds 4% or less of the time in the species that have been successfully cloned, In addition, some studies have indicated that cloned animals are less healthy than normally reproduced animals. The National Academy of Sciences, while supporting (2001) such so-called therapeutic or research cloning, has opposed (2002) the cloning of humans for reproductive purposes, deeming it unsafe, but many ethicists, religious and political leaders, and others have called for banning human cloning for any purpose.
See G. Kolata, Clone (1997).
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