George, who had suffered a short nervous breakdown in 1765 and a more serious one in 1788–89 (which caused a fierce conflict between Pitt and Fox over the powers to be vested in the regency), became permanently insane in 1810. It has been suggested that he was a victim of the hereditary disease porphyria. He spent the rest of his life in the care of his devoted wife, Charlotte Sophia, whom he had married in 1761, and the prince of Wales (later George IV) was made regent (see Regency). Unlike the first two Georges, George III had a tranquil domestic life, although scandal touched his brothers and sons. George was an honest and well-intentioned man, but his stubbornness and limited intellectual power confounded his efforts to rule well and made him a somewhat tragic figure.
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