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Medici[me´dichE, Ital. mA´dEchE] Pronunciation Key, Italian family that directed the destinies of Florence from the 15th cent. until 1737. Of obscure origin, they rose to immense wealth as merchants and bankers, became affiliated through marriage with the major houses of Europe, and, besides acquiring (1569) the title grand duke of Tuscany, produced three popes (Leo X, Clement VII, and Leo XI), two queens of France (Catherine de' Medici and Marie de' Medici), and several cardinals of the Roman Catholic Church. They also ruled for a brief period (1516–21) the duchy of Urbino.
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